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LY2584702 1082949-67-4

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Synonyms
Appearance
Chemical Formula
C21H19F4N7
Solubility
Molecular Weight
445.42
Storage and Stability
in stock
CAS No.
1082949-67-4
Purity
98%+
Introduction
In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM.  LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.
LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. 


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