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BAF312 1230487-00-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C29H35F3N2O3
Solubility ：
Molecular Weight ：
516.6
Storage and Stability ：
in stock
CAS No. ：
1230487-00-9
Purity ：
98%+
Introduction
BAF312 (Siponimod) is a potent and selective S1P receptor agonist, with EC50 of 0.39 nM and 0.98 nM for S1P1 and S1P5receptors, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. BAF312 (1 h at 1 μM) promotes prominent internalization of S1P1 receptors by 91%.

BAF312 effectively suppresses encephalomyelitis (EAE) in rats by internalizing S1P1 receptors, rendering them insensitive to the egress signal from lymph nodes.  BAF312 significantly reduces clinical scores when dosed prophylactically or therapeutically in mice at 0.3 mg/kg.

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