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XMD8-92 1234480-50-2

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Synonyms ：
Appearance ：
Chemical Formula ：
C26H30N6O3
Solubility ：
Molecular Weight ：
474.55
Storage and Stability ：
in stock
CAS No. ：
1234480-50-2
Purity ：
98%+
Introduction
XMD8-92, via inhibition of BMK1 activation, significantly induces p21 expression in cells, and mediates suppression of cancer cell proliferation. XMD8-92 markedly abrogates the inhibitive effects of hydroxysafflor yellow A (HSYA) on hepatic stellate cell (HSC) activation, and blockes the HSYA-mediated MEF2C down-regulation. 

XMD8-92 (50 mg/kg i.p.) significantly inhibit the growth of the xenografted human or syngeneic mouse tumors by blocking tumor cell proliferation and tumor-associated angiogenesis. XMD8-92 inhibits pancreatic tumor xenograft growth by significant downregulation of DCLK1 and several of its downstream targets.

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