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XEN445 1515856-92-4

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Synonyms
Appearance
Chemical Formula
C18H17F3N2O3
Solubility
Molecular Weight
366.33
Storage and Stability
in stock
CAS No.
1515856-92-4
Purity
98%+
Introduction
XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

XEN445 shows good in vitro inhibitory potency against EL, and high selectivity over LPL and HL. 

In vivo, XEN445 displays good ADME and PK properties. In mice, XEN445 (30 mg/kg, p.o.) raises plasma HDL-cholesterol concentration. 

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