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TAK-733 1035555-63-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H15F2IN4O4
Solubility ：
Molecular Weight ：
504.23
Storage and Stability ：
in stock
CAS No. ：
1035555-63-5
Purity ：
98%+
Introduction
TAK-733 is highly potent and selective MEK allosteric site inhibitor with IC50 of 3.2 nM. TAK-733 shows potent enzymatic and cell activity with an EC50 of 1.9 nM against ERK phosphorylation in cells. 

TAK-733 demonstrates broad antitumor activity in mouse xenograft models of human cancer including models of melanoma, colorectal, NSCLC, pancreatic and breast cancer. TAK-733 is well tolerated with pharmacokinetics and pharmacodynamics that support once-daily oral dosing in humans. TAK-733 shows maximally efficacious doses at once daily orally doses of 10 mg/kg. 

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