Skepinone-L 1221485-83-1

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Synonyms

：

Appearance

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Chemical Formula

：

C24H21F2NO4

Solubility

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Molecular Weight

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425.42

Storage and Stability

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in stock

CAS No.

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1221485-83-1

Purity

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98%+

Introduction

Skepinone-L shows concentration-dependent inhibition of HSP27 (Ser82) phosphorylation through the p38 MAPK pathway with a cellular IC50 of approximately 25 nM, and also reduces concentrations of TNF-α, IL-1β and IL-10, regulated by p38 MAPK, with IC50 ranging from 30 to 50 nM . Skepinone-L (1 μM) abrogates the phosphorylation of platelet p38 MAPK substrate Hsp27 activated by stimulation with CRP, thrombin or thromboxane A2 analogue U-46619, and impairs platelet secretion and aggregation.

In vivo, skepinone-L inhibits Gal/ LPS-induced TNF-α release by 77%.

Products for scientific research use only

Skepinone-L 1221485-83-1

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Skepinone-L 1221485-83-1

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