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Sal003 1164470-53-4

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Synonyms
Appearance
Chemical Formula
C18H15Cl4N3OS
Solubility
Molecular Weight
463.21
Storage and Stability
in stock
CAS No.
1164470-53-4
Purity
98%+
Introduction
Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells.  In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB). 

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