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Ro 61-8048 199666-03-0

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H15N3O6S2
Solubility ：
Molecular Weight ：
421.45
Storage and Stability ：
in stock
CAS No. ：
199666-03-0
Purity ：
98%+
Introduction
Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.

In gerbils and rats, Ro 61-8048 (30 mg/kg, p.o.) causes kynurenine 3-hydroxylase inhibition. In models of focal or global brain ischemia, Ro 61-8048 (40 mg/kg, p.o.) reduce ischemic brain damage.  In a hamster model of paroxysmal dyskinesia, Ro 61-8048 (150 mg/kg i.p.) significantly reduces the severity of dystonia without leading to marked central side effects.  addition, prenatal inhibition of the kynurenine pathway by Ro 61-8048 leads to structural changes in the hippocampus of adult rat offspring. 

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