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Necrostatin-1 4311-88-0

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Synonyms ：
Appearance ：
Chemical Formula ：
C13H13N3OS
Solubility ：
Molecular Weight ：
259.33
Storage and Stability ：
in stock
CAS No. ：
4311-88-0
Purity ：
98%+
Introduction
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.

Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.


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