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ML323 1572414-83-5

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Synonyms
Appearance
Chemical Formula
C23H24N6
Solubility
Molecular Weight
384.48
Storage and Stability
in stock
CAS No.
1572414-83-5
Purity
98%+
Introduction
ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.

ML323 inhibits the deubiquitination of PCNA and FANCD2 by inhibiting USP1–UAF1 activity in H596 cells. Moreover, ML323 potentiates cisplatin cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting two major DNA damage response pathways (TLS and FA). 

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