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Losmapimod 585543-15-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C22 H26 F N3 O2
Solubility ：
Molecular Weight ：
383.46
Storage and Stability ：
in stock
CAS No. ：
585543-15-3
Purity ：
98%+
Introduction
Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively

In spontaneously hypertensive stroke-prone rats (SHR-SP), Losmapimod significantly improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and subsequently attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1beta (IL-1beta)

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