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K02288 1431985-92-0

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Synonyms :
Appearance :
Chemical Formula :
C20H20N2O4
Solubility :
Molecular Weight :
352.38
Storage and Stability :
in stock
CAS No. :
1431985-92-0
Purity :
98%+
Introduction
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.

K02288 dose-dependently inhibits BMP4- and BMP6- induced Smad1/5/8 phosphorylation in C2C12 cells without affecting TGF-β-BMP signaling. 

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