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INH1 313553-47-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C18H16N2OS
Solubility ：
Molecular Weight ：
308.40
Storage and Stability ：
in stock
CAS No. ：
313553-47-8
Purity ：
98%+
Introduction
INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.

INH1 reduces the association of Hec1 with kinetochore and decreases global Nek2 protein level in cells. INH1 effectively inhibits the proliferation of human breast cancer lines with GI50 of 10-21 μM. Moreover, INH1 also elicits cell killing activity in part through impairing the Hec1/Nek2 pathway for the spindle checkpoint regulation. 

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