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HMN-214 173529-46-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C22H20N2O5S
Solubility ：
Molecular Weight ：
424.47
Storage and Stability ：
in stock
CAS No. ：
173529-46-9
Purity ：
98%+
Introduction
HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.

 
HMN-214 is an oral prodrug that is rapidly converted to HMN-176. The in vitro data of HMN-214 are scarce. However, HMN-176, active metabolite of HMN-214, shows potent and broad-spectrumanti-tumor activity against various cancer cells, including HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr, with a mean IC50 value of 118 nM. HMN-176 is also cytotoxic to drug-resistant human and murine cell lines, including P388/CDDP, P388/VCR, K2/CDDP, and K2/VP-16, with IC50 values ranging from 143 nM–265 nM. In HeLa cells, HMN-176 (3 μM) blocks cell cycle at G2/M phase.



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