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GNF-5837 1033769-28-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C28H21F4N5O2
Solubility ：
Molecular Weight ：
535.49
Storage and Stability ：
in stock
CAS No. ：
1033769-28-6
Purity ：
98%+
Introduction
GNF-5837 is a selective, and orally bioavailable pan-TRK inhibitor for TrkA, and TrkB with IC50 of 8 nM, and 12 nM, respectively.


In Ba/F3 cells overexpressing the constitutively active Tel-TRKC fusion, GNF-5837 shows potent anti-Trk activity and potent antiproliferation activity with IC50 of 0.042 μM. [1]


 
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