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BRD4770 1374601-40-7

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Synonyms ：
Appearance ：
Chemical Formula ：
C25H23N3O3
Solubility ：
Molecular Weight ：
413.47
Storage and Stability ：
in stock
CAS No. ：
1374601-40-7
Purity ：
98%+
Introduction
BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.

BRD4770 reduces cellular levels of di- and trimethylated H3K9 via inhibition of G9a, induces senescence, and inhibits both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. [1] The combination of gossypol and BRD4770 increases LC3-II levels and the autophagosome number, and thus acts in synergy to induce cell death in PANC-1 cells. [2]


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