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ABT-751 141430-65-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C18H17N3O4S
Solubility ：
Molecular Weight ：
371.41
Storage and Stability ：
in stock
CAS No. ：
141430-65-1
Purity ：
98%+
Introduction
ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.

In vitro, ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7–4.6 μM in other solid tumor cell lines. Furthermore, ABT-751 also exhibits a selective effect on dynamic microtubules and spares stable microtubules, accounting for the persistence of acetylated and detyrosinated α-tubulin positive polymerized tubules at the IC90 concentration of ABT-751.


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