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Ribociclib LEE011 1211441-98-3

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Synonyms
Appearance
Chemical Formula
C23H30N8O
Solubility
Molecular Weight
434.54
Storage and Stability
in stock
CAS No.
1211441-98-3
Purity
98%+
Introduction
Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.

Orally bioavailable CDK4/6-selective inhibitor that has been tested in Phase III clinical trials for treatment of advanced breast cancer.

LEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and cellular senescence.

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