Kartogenin 4727-31-5

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Synonyms

：

Appearance

：

Chemical Formula

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C20H15NO3

Solubility

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Molecular Weight

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317.34

Storage and Stability

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in stock

CAS No.

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4727-31-5

Purity

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98%+

Introduction

Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.

Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes. Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival.

Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice. Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis. In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development.

Kartogenin 4727-31-5

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Kartogenin 4727-31-5

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