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HTH-01-015 1613724-42-7

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Synonyms
Appearance
Chemical Formula
C26H28N8O
Solubility
Molecular Weight
468.55
Storage and Stability
in stock
CAS No.
1613724-42-7
Purity
98%+
Introduction
HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.

In HEK-293 cells express NUAK1 as well as NUAK2, HTH-01-015 suppresses NUAK1-mediated MYPT1 phosphorylation. HTH-01-015 suppresses cell migration In NUAK1+/+ MEFs, and inhibit U2OS cell invasion. Moreover, HTH-01-015 inhibits cell proliferation in both cell lines. HTH-01-015 inhibitors markedly restricted cells from entering into mitosis in U2OS cells.

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