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GSK2879552 2HCl 1401966-69-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C23H28N2O2.2HCl
Solubility ：
Molecular Weight ：
437.4
Storage and Stability ：
CAS No. ：
1401966-69-5
Purity ：
98%+
Introduction
GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.

In 165 cell lines, GSK2879552 inhibits the growth of 9/28 small cell lung carcinoma (SCLC) lines and 20/29 AML lines ranged from 40% to 100%. The subset of SCLC lines and primary samples that undergo growth inhibition in response to GSK2879552 exhibit DNA hypomethylation of a signature set of probes.

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