ABC294640 915385-81-8

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Synonyms

：

Appearance

：

Chemical Formula

：

C23H25ClN2O

Solubility

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Molecular Weight

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380.91

Storage and Stability

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in stock

CAS No.

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915385-81-8

Purity

：

98%+

Introduction

ABC294640 is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.

ABC294640 markedly alters the ratio of ceramide/S1P consistent with inhibition of SK activity in MDA-MB-231 cells. ABC294640 inhibits tumor cell proliferation with IC50 values ranging from approximately 6 to 48 μM, and impairs tumor cell migration concomitant with loss of microfilaments. ABC294640 induces nonapoptotic cell death, morphological changes in lysosomes, formation of autophagosomes, and increases in acidic vesicles in A-498, PC-3, and MDA-MB-231 cells. In both MCF-7 and ER-transfected HEK293 cells, ABC294640 decreases E2-stimulated ERE-luciferase activity.

ABC294640 915385-81-8

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ABC294640 915385-81-8

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CAS No. ：

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