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IPI145 1201438-56-3

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Synonyms ：
Appearance ：
white powder
Chemical Formula ：
C22H17ClN6O
Solubility ：
Molecular Weight ：
416.86
Storage and Stability ：
in stock
CAS No. ：
1201438-56-3
Purity ：
99.5%
Introduction
Duvelisib (IPI-145) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM, highly selective for PI3K δ/γ than other protein kinases. IC50 value: 1 nM/50 nM (PI3K δ/γ) [1] Target: PI3K δ/γ in vitro: IPI-145 suppresses murine/human B-cell proliferation with EC50 of 0.5 nM/0.5 nM and also inhibits human T-cell proliferation with EC50 of 9.5 nM . in vivo: IPI-145 (10 mg/kg, p.o.) shows well pharmacokinetics with Cmax and AUC of 390 ng/mL and 137 ng/mL in mouse and rat. IPI-145 (10 mg/kg) is active in murine DTH model with ~50% ear swelling. IPI-145 (10 mg/kg) demonstrates dose-dependent effect in rat collagen induced arthritis (CIA) model. IPI-145 prevents inflammation and protects joint bone and cartilage in the rat CIA model. IPI-145 (10 mg/kg,QD) demonstrates activity in rat adjuvant induced polyarthritis model .

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