Briciclib ON014185 865783-99-9

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Synonyms

：

Appearance

：

white powder

Chemical Formula

：

C19H23O10PS

Solubility

：

Molecular Weight

：

474.42

Storage and Stability

：

in stock

CAS No.

：

865783-99-9

Purity

：

99.5%

Introduction

Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. Target: Cyclin D1 in vitro: Briciclib inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM). [1] Cyclin D1 is a protein required for normal progression through the cell cycle and is overexpressed in many tumors. Cyclin D1 expression is regulated through a process termed cap-dependent translation, which requires the function of eukaryotic initiation factor 4E (eIF4E) protein. In vitro evidence indicates that briciclib binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins (c-MYC, VEGF), leading to tumor cell death. Briciclib is potent and shown to be active in nonclinical tumor models when combined with several chemotherapeutics.

Briciclib ON014185 865783-99-9

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Briciclib ON014185 865783-99-9

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